Interaction of Laser Beam and Gold Nanoparticles, Study of Scattering Intensity and the Effective Parameters

Document Type : Articles


Department of Physics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran


 In this paper, the optical properties of gold nanoparticles investigated. For this purpose the scattering intensity of a laser beam incident on gold nanoparticles has been studied using Mie theory and their respective curves versus different parameters such as scattering angle, wavelength of the laser beam and the size of gold nanoparticles are plotted. Investigating and comparison of the depicted plots show that the scattering intensity increases with increasing gold nanoparticles size up to 100 nm and further increasing of nanoprticles sizes leads to oscillating like behavior in the intensity patterns. Several peaks emerges in the patterns of intensity versus nanoparticle size. It was also found that for particles with sizes less than 100 nm the intensity patterns versus wavelength had a one peak about 520 nm while for the particles bigger than 100 nm there appears other maxima in different wavelength too. Changing the angle of scattering led to change in the intensity pattern of scattered light and its minimum value was detected at 90°. These results can be used in detecting cancerous tumors and in cancer therappy.


[1]    Charles P. Poole, Jr. Frank J. Owens, Introduction to nanotechnology, Wiley- Interscience, 2003.
[2]    X. Huang and M.A. El-Sayed, Gold nanoparticles: optical properties and implementation in cancer diagnosis and photothermal therapy, Journal of advanced research, 1 ( 2010) 13-28.
[3]    Matthews., Kanwar, R.K., Zhou, Sh., Punj, V.,  Kanwar, J.R., Applications of Nanomedicine in Antibacterial   Medical Therapeutics and Diagnostic, The Open Tropical Medicine Journal, 3 (2010) 1-9.
[4] G. A. Mie, contribution to the optics of turbid media, especially Colloidal metallic suspensions, Ann. Phys., 25 (1980) 377–445.
[5] P.M. Prajapati, Y. Shah  and  D.J. Sen, Gold Nanoparticles: A new approach for cancer Detection, Journal of Chemical and Pharmaceutical Research,2 (1) (2010) 30-37.
[6] L. Brannon-Peppas and Blanchette, Nanoparticle and targeted systems for cancer therapy, Advanced Drug Delivery Reviews, 56 (2004) 1649-1659.
 [7] J. Yu, D. Y. Huang, M. Z. Yousaf, Y. L. Hou and S. Gao, Magnetic nanoparticle-based cancer therapy, Chin Phys B. 22 (2013) 027506.
[8] P. F. Jiao, H. Y. Zhou, L. X. Chen and B. Yan, Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy, Curr. Med. Chem. 18 (14) (2011) 2086-2102.
[9] S . Jain, D. G. Hirst and J. M. O’Sullivan, Gold nanoparticles as novel agents for cancer therapy,  Br. J. Radiol., 85 (2012) 101.
[10] M. Wang  and  M . Thanou, Targeting nanoparticles to cancer, Pharmacol. Res. 62 (2010) 90.
[11] A. Kumar, H. Ma, X . Zhang, K. Huang, S. Jin, J. Liu, T. Wei, W. Cao, G. Zou and X. J. Liang, Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment, Biomaterials, 33 (2012) 1180-1189.
[12] E. C. Dreaden, L.A.  Austin, M.A. Mackey and M. A. El-Sayed, Size matters: gold nanoparticles in targeted cancer drug delivery, Therapeutic Delivery, 3 (4) (2012) 457.
[13] P. R. Gil and W. J. Parak, Composite Nanoparticles Take Aim at Cancer, ACS Nano, 2 (2008) 2200-2205.
[14] X. Huang and M. A. El-Sayed, The Ongoing History of Thermal Therapy for Cancer, Alexandria J. Med. 47 (2011) 1.
[15] E.S. Glazer and S. A. Curley, The Ongoing History of Thermal Therapy for Cancer, Surg. Oncol. Clin. N. Am. 20 (2011) 229.
[16] X. L. Yue, F.  Ma and Z. F. Dai, Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer, Chin. Phys. B, 23 (2014) 044301.
[17] E.S. Shibu, M . Hamada, N . Murase and V. Biju,  Nanomaterials formulations for photothermal and photodynamic therapy of cancer, J. Photochem. Photobiol. C Photochem. Rev. 15 (2013) 53.
[18] E. B. Dickerson, E.C. Dreaden, X . Huang,  I. H.  El-Sayed, H . Chu, S. Push-panketh, J.F. McDonald and M. A. El-Sayed, Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice, Cancer Lett. 269 (2008) 57-66.
[19] A. M. Gobin, M. H. Lee, Halas, N.J. James,  R.A. Drezek and J.L. West, Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy, Nano Lett. 7 (2007) 1929.
[20] M.P. Melancon , M. Zhou  and C.Li, Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles, Acc. Chem. Res. 44 (2011) 947.
[21] W.Il . Choi,  A . Sahu , Y. H. Kim and G. Tae, Photothermal Cancer Therapy and Imaging Based on Gold Nanorods, Ann. Biomed. Eng. 40 (2012) 534.
[22] N. Rozanova and J. Zhang, Photothermal ablation therapy for cancer based on metal nanostructures, Sci. China, Ser. B Chem. 52 (2009) 1559.
[23] M.A.  MacKey,  M. R. K. Ali, L.A. Austin, R. D. Near and M.A. El-Sayed, The Most Effective Gold Nanorod Size for Plasmonic Photothermal Therapy: Theory and In Vitro Experiments, J. Phys. Chem. B, 118 (2014) 1319.
[24] D.K. Kirui, S. Krishnan, A.D. Strickland and C.A. Batt, PAA-Derived Gold Nanorods for Cellular Targeting and Photothermal Therapy, Macromol. Biosci. 11 (2011) 779.

[25] S. Abbasi, M. Servatkhah, M.M. Keshtkar, Advantages of using gold hollow nanoshells in cancer photothermal therapy, Chinese Physics B, 25 (2016) 087301.

[26] M. Quinten, Optical Properties of Nanoparticle Systems, Wiley-VCH Verlag & Co . KGaA, Boschstr. Weinheim, Germany, 2011.
[27] H.C. van de. Hulst, Light scattering by small particles. John Wiley & Sons, New York, 1957.
[28] P. B. Johnson and R.W. Christy, Optical Constants of the   Noble Metals, PHYSICAL REVIEW B, 6 (12) (1972) 4370- 4378.